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June 19, 2026Minerva Surgery

Synchronous colorectal liver metastases: short- and long-term outcome analysis of staged versus simultaneous resection

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Authors

MSMaria C. STYLIANIDISVSascha VaghiriLFLiubou FEDARENKA

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Overview

Retrospective analysis compares outcomes of staged and simultaneous surgical approaches for liver metastases.

Key Points

  • This analysis aims to compare the short- and long-term outcomes of staged versus simultaneous resections for synchronous colorectal liver metastases.
  • Retrospective analysis of 138 patients with synchronous colorectal liver metastases.
  • Patients categorized into two groups: staged (N=83) and simultaneous (N=55) resection.
  • Outcome measures included postoperative complications, hospital stay, overall survival, and disease-free survival.
  • Major liver resections were more common in the staged group (57.83%) than in the simultaneous group (23.64%), P=0.001.
  • Hospital stay was significantly longer after simultaneous resection (37.1 days) compared to staged (25.7 days), P=0.022.
  • Median disease-free survival was better in the staged group (27.3 months) compared to the simultaneous approach (14.6 months), P=0.019.

Cite This Study

STYLIANIDI et al. (2026) studied this question.

synapsesocial.com/papers/6a34de1265a5b0777af2d8a1https://doi.org/10.23736/s2724-5691.26.11099-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study”2025 · 2 citations
  2. 2Staged resection versus simultaneous resection for conversion surgery for initially unresectable colorectal liver metastasis: A prospective cohort study.2024
  3. 3Outcomes of Simultaneous Versus Staged Resection for Stage IV Colorectal Cancer with Synchronous Liver Metastases2024 · 2 citations
  4. 4Surgical Resection in Colorectal Liver Metastasis: An Umbrella Review2024 · 4 citations
  5. 5Simultaneous versus staged resection for conversion surgery in initially unresectable colorectal liver metastases: a multicenter prospective cohort study2025