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November 14, 2025International Journal of SurgeryOpen Access

Simultaneous versus staged resection for conversion surgery in initially unresectable colorectal liver metastases: a multicenter prospective cohort study

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Authors

YCYijiao ChenJZJunchang ZhuPXPingping Xu

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Overview

Prospective cohort study reveals staged resection improves safety and relapse-free survival in colorectal liver metastases patients, suggesting a preferred surgical approach.

Key Points

  • This research aims to compare the safety and oncologic efficacy of simultaneous versus staged resection in patients with initially unresectable colorectal liver metastases.
  • Multicenter prospective cohort study across three centers
  • Enrolled 366 patients with initially unresectable colorectal liver metastases
  • Compared simultaneous and staged surgical resection approaches
  • Staged resection showed lower overall complications at 35.8% compared to 48.9% for simultaneous surgery
  • Staged resection improved relapse-free survival with HR = 0.780, P = 0.030
  • Staged resection had better liver-specific relapse-free survival with HR = 0.737, P = 0.011
  • No significant difference in overall survival with HR = 0.811, P = 0.188

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/692519b4c0ce034ddc354595https://doi.org/10.1097/js9.0000000000003982
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Staged resection versus simultaneous resection for conversion surgery for initially unresectable colorectal liver metastasis: A prospective cohort study.2024
  2. 2Synchronous colorectal liver metastases: short- and long-term outcome analysis of staged versus simultaneous resection2026
  3. 3Surgical Resection in Colorectal Liver Metastasis: An Umbrella Review2024 · 4 citations
  4. 4“Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study”2025 · 2 citations
  5. 5Outcomes of Simultaneous Versus Staged Resection for Stage IV Colorectal Cancer with Synchronous Liver Metastases2024 · 2 citations