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June 14, 2026Veterinary Medicine and ScienceOpen Access

Pharmacokinetics and Bioavailability of Tolfenamic Acid in Calves: First Evaluation of Subcutaneous Administration

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Authors

OÇOrhan ÇorumMustafa Kemal University PMPedro MarínUniversidad de Murcia EBElena BadilloUniversidad de Murcia

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Implication

Randomized trial evaluated pharmacokinetics and bioavailability of tolfenamic acid in calves, indicating the need for route-specific dosing considerations.

Key Points

This study aimed to evaluate the pharmacokinetics and bioavailability of tolfenamic acid in calves after different routes of administration.
Six calves received tolfenamic acid at a dose of 4 mg/kg via subcutaneous, intramuscular, and intravenous routes in a crossover design.
Plasma concentrations were measured to assess pharmacokinetics and bioavailability.
Terminal elimination half-life increased from IV (6.64 h) to IM (12.79 h) and SC (15.11 h).
Systemic exposure after SC administration was approximately half of that after IM injection, indicating lower bioavailability.
Plasma concentrations exceeded EC 50 values for up to 24 h after IV and 48 h after IM or SC administration.

Cite This Study

Çorum et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4855b1cc60ccdea8c99a https://doi.org/10.1002/vms3.71024

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June 14, 2026Veterinary Medicine and ScienceOpen Access

Pharmacokinetics and Bioavailability of Tolfenamic Acid in Calves: First Evaluation of Subcutaneous Administration

View Full Paper

Ask AI

Bookmark

Authors

OÇOrhan ÇorumMustafa Kemal University PMPedro MarínUniversidad de Murcia EBElena BadilloUniversidad de Murcia

Discussion

Member takes

Implication

Randomized trial evaluated pharmacokinetics and bioavailability of tolfenamic acid in calves, indicating the need for route-specific dosing considerations.

Key Points

This study aimed to evaluate the pharmacokinetics and bioavailability of tolfenamic acid in calves after different routes of administration.
Six calves received tolfenamic acid at a dose of 4 mg/kg via subcutaneous, intramuscular, and intravenous routes in a crossover design.
Plasma concentrations were measured to assess pharmacokinetics and bioavailability.
Terminal elimination half-life increased from IV (6.64 h) to IM (12.79 h) and SC (15.11 h).
Systemic exposure after SC administration was approximately half of that after IM injection, indicating lower bioavailability.
Plasma concentrations exceeded EC 50 values for up to 24 h after IV and 48 h after IM or SC administration.

Cite This Study

Çorum et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4855b1cc60ccdea8c99a https://doi.org/10.1002/vms3.71024

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