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September 10, 2025AnimalsOpen Access

Pharmacokinetics of Tolfenamic Acid Administered Orally and Intravenously at Different Doses in Pekin Ducks (Anas platyrhynchos domestica)

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Authors

OÇOrhan ÇorumKÜKamil ÜneyPMPedro Marı́n

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Overview

This study examines the pharmacokinetics of tolfenamic acid in Pekin ducks, revealing dose-dependent effects on bioavailability and plasma protein binding.

Key Points

  • Tolfenamic acid's pharmacokinetics showed significant differences based on administration route and dosage.
  • For the 2 mg/kg IV dose, AUC0-∞ was 13.03 h*µg/mL, with clearance rate at 0.15 L/h/kg and half-life at 1.72 h.
  • Oral administration (2 mg/kg) yielded a bioavailability of 48.52%, with peak plasma concentration significantly elevated.
  • Plasma protein binding for tolfenamic acid was found to be 99.74%, consistent across all tested concentrations.

Cite This Study

Çorum et al. (2025) studied this question.

synapsesocial.com/papers/68c1c62f54b1d3bfb60f1d16https://doi.org/10.3390/ani15162326
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