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June 14, 2026

Epigenetic mechanisms in preeclampsia: translational therapeutic strategies and precision-medicine perspectives.

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Authors

OCO CreţuCPCristian PoalelungiANAdrian Neacşu

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Overview

Review evaluates epigenetic factors influencing preeclampsia, suggesting novel therapeutic strategies for improved outcomes.

Key Points

  • This review aims to integrate epigenetic mechanisms of preeclampsia with potential therapeutic applications and precision-medicine approaches.
  • Review of epigenetic pathways involved in preeclampsia
  • Discussion of various therapeutic strategies targeting these pathways
  • Evaluation of barriers to translating these findings into clinical practice.
  • Identified epigenetic pathways as critical therapeutic entry points in managing preeclampsia.
  • Proposed several interventions, including modulation of DNMT and HDAC activities and microRNA strategies.
  • Outlined key translational barriers such as tissue specificity and regulatory issues.

Cite This Study

Creţu et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4855b1cc60ccdea8ca2ahttps://doi.org/10.25122/jml-2026-0058
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotype-stratified Targeted Therapy for Preeclampsia: A Biomarker-guided, Mechanism-driven Systematic Review Integrating Oxidative Stress, Metabolic Dysfunction, Immune Injury, and Placental Vasculopathy2026
  2. 2Epigenetic alterations in preeclampsia: a systematic review of current mechanisms and biomarker potential.2026
  3. 3Understanding Preeclampsia: Integrating Placental Dysfunction, Immune Dysregulation and microRNA-Mediated Epigenetic Regulation2026 · 1 citations
  4. 4Molecular Subtypes of Preeclampsia and the Emergence of Precision Obstetric Phenotyping: A Systematic Review of Transcriptomic, Multiomic, and Clinical Integration Frameworks2026
  5. 5Molecular Signatures of Preeclampsia: The Role of Post‐Translational Protein Modifications2026 · 3 citations