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April 15, 2026Journal of Applied Sciences and Clinical PracticeOpen Access

Molecular Subtypes of Preeclampsia and the Emergence of Precision Obstetric Phenotyping: A Systematic Review of Transcriptomic, Multiomic, and Clinical Integration Frameworks

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Authors

WPWisnu PrabowoWAWiku AndonotopoMBMuhammad Adrianes Bachnas

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Overview

A systematic review reveals distinct molecular subtypes of preeclampsia, suggesting tailored prevention strategies.

Key Points

  • This review aims to synthesize diverse molecular insights into preeclampsia and propose a precise classification.
  • Conducted a systematic review of studies on preeclampsia without time restrictions.
  • Assessed 33 studies utilizing transcriptomic, proteomic, metabolomic, or epigenomic data.
  • Applied Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines for evaluation.
  • Explored integration of multiomic findings with maternal clinical data.
  • Identified distinct molecular constellations related to preeclampsia, including inflammatory and vascular pathways.
  • Integrated models were found to predict onset weeks before symptoms with better accuracy.
  • Highlighted the potential for individualized prevention strategies, such as tailored aspirin use and metabolic support.

Cite This Study

Prabowo et al. (2026) studied this question.

synapsesocial.com/papers/69df2b04e4eeef8a2a6affc6https://doi.org/10.4103/jascp.jascp_38_25
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Also Consider

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  1. 1Phenotype-stratified Targeted Therapy for Preeclampsia: A Biomarker-guided, Mechanism-driven Systematic Review Integrating Oxidative Stress, Metabolic Dysfunction, Immune Injury, and Placental Vasculopathy2026
  2. 2Abstract 58: Clinical and Biomarker Subtypes of Preeclampsia and Future Cardiovascular Health2026
  3. 3Rethinking Risk Prediction in Preeclampsia: From Biomarkers to Mechanistic Phenotypes and Longitudinal Models2026
  4. 4Epigenetic mechanisms in preeclampsia: translational therapeutic strategies and precision-medicine perspectives.2026
  5. 5Genomic Insights at the Maternal-Fetal Interface: Preeclampsia Subtypes and Clinical Implications2025