Key result
Multimodality imaging quantifies aortic stenosis severity by assessing valve calcification and metabolic activity.
Why the study?
Aortic stenosis progression is an active metabolic process, and multimodality imaging can assess aortic valve calcification, metabolic activity, and disease severity.
Multimodality imaging provides valuable checkpoints for assessing aortic valve calcification and metabolic activity, which can help quantify disease severity and serve as targets in clinical trials.
Multimodality imaging aids aortic stenosis assessment; leaves open prospective validation before routine therapeutic guidance.
Calcific aortic stenosis primarily affects the aging population and is associated with significant morbidity and mortality. The progression of aortic stenosis from sclerotic aortic valve to severe aortic stenosis is an active metabolic process that involves multiple signaling pathways. Multimodality imaging can assess aortic valve calcification and metabolic activity and quantify severity of disease. This review describes the clinical utility of echocardiography, cardiac magnetic resonance imaging, cardiac computed tomography, and nuclear imaging in the assessment of aortic stenosis. These imaging checkpoints may also serve as targets of clinical research trials aimed at halting the progression of aortic stenosis.
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Jain et al. (2026) conducted a review in Aortic stenosis. Multimodality imaging was evaluated. Multimodality imaging, including echocardiography, CMR, CT, and nuclear imaging, can assess aortic valve calcification and metabolic activity to quantify the severity of aortic stenosis.
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