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September 30, 2022Open Access

Short Sleep Duration Associated with the Incidence of Cardio-Cerebral Vascular Disease: a Prospective Cohort Study in Shanghai, China

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Key result

Short sleep duration (≤ 5 hours per day) was associated with a 70% higher risk of incident cardio-cerebral vascular disease compared to 7 hours of sleep per day (HR 1.70).

Why the study?

The association between sleep duration and predicted cardio-cerebral vascular disease risk remains to be fully understood.

Does short sleep duration increase the incidence of cardio-cerebral vascular disease in Chinese community residents?

Population

6476 Chinese community residents who underwent follow-up examination (from 9247 initially enrolled)

Comparison

Self-reported sleep duration categories (≤5, 6, 8, or ≥9 hours per day vs 7 hours per day)

Design

Prospective cohort study

Follow-up

Median 3.00 years (IQR 2.83-3.08)

Authors

JKJuzhong KeXLXiaolin LiuXRXiaonan Ruan

Discussion

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Member takes

Overview

Short sleep may elevate CCVD risk; leaves open causality and need for interventional trials.

Study Design

Type

Cohort (n=6,476)

Structured PICO

Does short sleep duration increase the incidence of cardio-cerebral vascular disease in Chinese community residents?

P
Population
6,476 Chinese community residents (mean age 58.2 years, 62.9% female) free of prior cardio-cerebral vascular disease, followed for a median of 3.00 years.
E
Exposure
Self-reported short sleep duration (≤5 hours per day)
C
Comparator
Self-reported sleep duration of 7 hours per day (reference group)
O
Outcome
Cardio-cerebral vascular disease (CCVD) incidence, defined as a physician diagnosis or death of coronary heart disease (CHD) or stroke during follow-uphard clinical

Main Result

Hazard Ratio: 1.7 (95% CI 1.24–2.34)

Absolute Event Rate: 37.67% vs 18.33%

p-value: p=0.001

Short sleep duration (≤5 hours) is independently associated with a significantly increased risk of incident cardio-cerebral vascular disease, particularly in individuals under 65 and those with baseline hypertension.

Limitations

  • Information about sleep duration and quality were obtained through questionnaires, which may have discrepancies with objective measures.
  • The follow-up period of this study was relatively short.
  • Possibility of residual or unmeasured confounding despite adjusting for potential confounders.
  • Information about sleep duration and quality were obtained through questionnaires, which may have a discrepancy with objective measures.
  • The follow-up period of the study was relatively short.
  • Possibility of residual/unmeasured confounding cannot be ruled out.

Cite This Study

Ke et al. (2022) conducted a cohort in Cardio-cerebral vascular disease (CCVD) (n=6,476). Short sleep duration (≤ 5 hours/day) vs. 7 hours/day sleep duration was evaluated on CCVD incidence (HR 1.70, 95% CI 1.24-2.34, p=0.001). Short sleep duration (≤ 5 hours per day) was associated with a 70% higher risk of incident cardio-cerebral vascular disease compared to 7 hours of sleep per day (HR 1.70).

synapsesocial.com/papers/6a2ea4a866e347ad8cd63bbehttps://doi.org/10.21203/rs.3.rs-2086782/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sleep Duration, Insomnia, and Coronary Heart Disease Among Postmenopausal Women in the Women's Health Initiative2013 · 151 citations
  2. 2Association of Sleep Duration and Hypertension Among US Adults Varies by Age and Sex2011 · 139 citations
  3. 3Global Atlas of Cardiovascular Disease 2000-2016: The Path to Prevention and Control2018 · 449 citations
  4. 4Infections, atherosclerosis, and coronary heart disease2017 · 245 citations
  5. 5Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies2017 · 733 citations