Key result
Predicted 10-year CVD risk using SCORE2 varied several-fold across European regions for individuals with identical traditional risk factor profiles.
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“This risk tool is much more powerful and superior than what doctors have used for decades. It will fit seamlessly into current prevention programmes with substantial real-world impact by improving the prevention of cardiovascular diseases across Europe before they strike.”
“This project was a highly collaborative effort that has brought together key experts and extensive data sources to develop improved risk prediction tools for cardiovascular disease for use across the UK and Europe. A key feature is that our calculators are relevant to current day rates of cardiovascular disease in different regions of Europe. Importantly, our methods allow them to be easily updated using routinely collected data in the future to ensure they stay relevant as trends in heart and circulatory diseases change.”
“Heart and circulatory diseases are the world's biggest killers, impacting the lives of 7.6 million people across the UK alone. This new risk tool is a major advance and will save many more people from developing heart attacks, stroke and heart disease, all of which develop silently over many years and strike without warning.”
The SCORE2 algorithm highlights significant regional variations in CVD risk across Europe that are not captured by traditional risk factors alone.
ranged from 0.67 to 0.81. Predicted CVD risk varied several-fold across European regions. For example, their results suggested that the estimated 10-year CVD risk for a 50-year-old smoker, with a systolic blood pressure of 140 mmHg, total cholesterol of 5.5 mmol/L, and HDL-cholesterol of 1.3 mmol/L, ranged from 5.9% for men in low-risk countries to 14.0% for men in very high-risk countries, and from 4.2% for women in low-risk countries to 13.7% for women in very high-risk countries.
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Filippo Crea (2021) conducted an editorial in Cardiovascular disease risk. SCORE2 risk prediction algorithms was evaluated on 10-year CVD risk. Predicted 10-year CVD risk using SCORE2 varied several-fold across European regions for individuals with identical traditional risk factor profiles.
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