Key result
Homozygosity for the -93g allele in the LPL gene promoter was associated with lower plasma triglyceride levels compared to the -93t allele (0.82 vs 1.14 mmol/L; P=0.04).
Why the study?
Does the -93g allele in the LPL gene promoter affect plasma triglyceride levels compared to the -93t allele?
Population
Caucasians (n=232), South African Blacks (n=161), and a Chinese cohort
Comparison
Homozygous for the -93g allele in the… vs Homozygous for the -93t allele in the LPL gene…
Design
Cross-sectional
Authors
Loading...
May inform ethnic lipid variation; leaves open cardiovascular outcome implications.
Observational
Yes
Does the -93g allele in the LPL gene promoter affect plasma triglyceride levels compared to the -93t allele?
Absolute Event Rate: 0.82% vs 1.14%
p-value: p=0.04
The -93g allele in the LPL gene promoter is highly prevalent in South African Blacks and is associated with lower plasma triglyceride levels.
Ehrenborg et al. (1997) reported an observational. Homozygosity for the -93g allele in the LPL gene promoter vs. Homozygosity for the -93t allele was evaluated on Plasma triglyceride levels (p=0.04). Homozygosity for the -93g allele in the LPL gene promoter was associated with lower plasma triglyceride levels compared to the -93t allele (0.82 vs 1.14 mmol/L; P=0.04).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: