January 1, 1998Clinical Genetics
The Asn9 variant of lipoprotein lipase is associated with the — 93G promoter mutation and an increased risk of coronary artery disease
Why the study?
Does the -93G/Asn9 variant of the LPL gene increase the risk of coronary artery disease and alter lipid profiles in men?
Population
1,058 Dutch males, comprising 762 with angiographically-diagnosed coronary artery disease and 296 healthy…
Comparison
Presence of the -93G/Asn9 allele vs Non-carriers of the -93G/Asn9 allele
Design
Case-control
Authors
Discussion
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Member takes
Implication
Does not support clinical use of LPL genotyping; leaves open replication in prospective cohorts.
Structured PICO
Does the -93G/Asn9 variant of the LPL gene increase the risk of coronary artery disease and alter lipid profiles in men?
P
Population
1,058 Dutch males, comprising 762 with angiographically-diagnosed coronary artery disease (CAD) and 296 healthy normolipidemic controls.
I
Intervention
Presence of the -93G/Asn9 allele (carriers of the LPL Asp9Asn mutation and -93G promoter mutation)
C
Comparator
Non-carriers of the -93G/Asn9 allele
O
Outcome
Risk of coronary artery disease (CAD)
The combined -93G/Asn9 genotype of the LPL gene is associated with decreased HDL-C levels and a significantly increased risk of coronary artery disease.
Cite This Study
Kastelein et al. (1998) studied this question.