Why the study?
Is the lipoprotein lipase Asn291Ser variant associated with dyslipidemia, T2DM, and CHD in white subjects?
Population
19,246 white subjects from 21 articles
Comparison
Carriers of the lipoprotein lipase Asn291Ser… vs Noncarriers of the LPL Asn291Ser variant
Design
Meta-analysis
Authors
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May inform genetic risk assessment for dyslipidemia in whites; extends meta-analytic support for LPL Asn291Ser in adverse lipids and cardiometabolic outcomes.
Is the lipoprotein lipase Asn291Ser variant associated with dyslipidemia, T2DM, and CHD in white subjects?
The LPL Asn291Ser variant is a significant genetic risk factor for dyslipidemia (hypertriglyceridemia and low HDL-C), T2DM, and CHD in white populations.
Hu et al. (2006) studied this question.
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