Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus

696 subjects, comprising 192 patients with Type 2 diabetes, 278 subjects with normal glucose tolerance who are first-degree relatives of patients with Type 2 diabetes, and 226 healthy control spouses without family history of diabetes.

Presence of the Asn291Ser variant of the LPL gene and insulin resistance (estimated using HOMA index)

Absence of the Asn291Ser variant and varying levels of insulin sensitivity

Dyslipidaemia (hypertriglyceridaemia > 1.7 mmol/l) and systolic blood pressuresurrogate