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June 15, 2026Brain and BehaviorOpen Access

Integrated Blood Inflammatory Ratios and Cerebrospinal Fluid Blood‒Brain Barrier Dysfunction Predict Relapse Risk in Neuromyelitis Optica Spectrum Disorder

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Authors

XZXingyue ZhengJSJing ShiHYHao Yin

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Overview

Retrospective cohort study develops a prognostic model for NMOSD relapse risk, suggesting better management strategies.

Key Points

  • This research aims to create a prognostic model integrating blood and cerebrospinal fluid parameters to predict relapse risk in NMOSD.
  • Retrospective cohort study involving 152 NMOSD patients followed for time to first relapse.
  • Collected baseline inflammatory indices (NLR, MLR) and CSF parameters indicating BBB function.
  • Used multivariable Cox regression to identify predictors and evaluated model performance through ROC analysis and decision curve analysis.
  • Relapsing patients showed increased BBB dysfunction and heightened systemic inflammation at baseline.
  • Integrated model achieved an AUC of 0.850, demonstrating superior discrimination compared to clinical (0.693) and clinical-CSF models (0.744).
  • Higher AQP4-IgG levels correlated with increased relapse risk, indicating the model's effectiveness beyond serological status.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/6a2f97c8a1cfeec490828d71https://doi.org/10.1002/brb3.71481
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood‐based inflammatory protein biomarker panel for the prediction of relapse and severity in patients with neuromyelitis optica spectrum disorder: A prospective cohort study2024 · 8 citations
  2. 2Predictors of relapse risk and treatment response in AQP4-IgG positive and seronegative NMOSD: A multicentre study2024 · 14 citations
  3. 3Prognostic Biomarker Signature of Relapse in Neuromyelitis Optica Spectrum Disorders in the CIRCLES Observational Study2026
  4. 4Relapse-related outcomes in the Danish population-based AQP4- antibody seropositive neuromyelitis optica spectrum disorder cohort2026
  5. 5Serum brain injury biomarkers in patients with NMOSD: dynamic changes and clinical significance2026