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This publication examines how ions influence hydration architecture in DNA, impacting enzyme interactions.
This publication develops a geometric–temporal framework in which ions are considered not only as electrostatic charges, but as ion-hydration regimes capable of stabilizing or disrupting groove-specific hydration architecture. The central thesis is that ions modify the local water architecture around DNA grooves, and through this modification affect hydration readability and the DNA–enzyme meeting window.
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Balevsky et al. (2026) studied this question.
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