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June 15, 2026Open Access

Anti-Osteoporotic and Bone-Healing Potential of Cissus Quadrangularis: A Review

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Authors

GPG. Gnanamoorthy*1, Dr. S. Parthasarathi2, Dr. Ranjith2, H. Aarthi1, S. Lakshmi1, M. Prakash

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Overview

Review shows Cissus quadrangularis may improve bone health in patients, suggesting a positive impact on healing.

Key Points

  • To overview the therapeutic potential of Cissus quadrangularis in bone health, focusing on biomarkers and fracture healing.
  • Review of clinical studies on Cissus quadrangularis supplementation and its effects on bone health.
  • Evaluation of serum biomarker levels, including parathyroid hormone, calcium, phosphorus, and alkaline phosphatase.
  • Assessment of clinical outcomes like pain reduction, swelling, inflammation, and bone healing in patients with fractures.
  • Cissus quadrangularis increased serum parathyroid hormone levels, indicating a stimulatory effect on bone remodeling.
  • Clinical studies showed faster healing in fracture patients with reduced pain and inflammation, but no significant changes in calcium, phosphorus, or alkaline phosphatase levels.
  • Placebo-controlled studies showed that Cissus quadrangularis may slow bone loss in postmenopausal women, though significant increases in bone mineral density were not observed.

Cite This Study

G. Gnanamoorthy*1, Dr. S. Parthasarathi2, Dr. Ranjith2, H. Aarthi1, S. Lakshmi1, M. Prakash (2026) studied this question.

synapsesocial.com/papers/6a2f984ba1cfeec49082944fhttps://doi.org/10.5281/zenodo.20678386
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the Role of Cissus quadrangularis in Osteoporosis Management2026
  2. 2Phytochemical and Pharmacological Evaluation of Cissus quadrangularis Linn2025
  3. 3Phyto-Pharmacognostical Standardization of Three Morpho-Variants of Cissus quadrangularis L.2024 · 5 citations
  4. 4A COMPREHENSIVE REVIEW CISSUS QUADRANGULARIS PHYTOCHEMISTRY, PHARMACOLOGICAL POTENTIAL, AND THE OVERLOOKED PROBLEM OF ECOTYPE-DRIVEN VARIABILITY2026
  5. 5The Study to Assess the Effectiveness of Cissus Quadrangularis among Postmenopausal Women with Osteopenia2024 · 1 citations