What question did this study set out to answer?

To evaluate the pharmacognostic profile of Cissus quadrangularis, isolate its primary bioactive constituents, and assess their therapeutic potential via computational modeling.

February 13, 2026Discover Pharmaceutical SciencesOpen Access

Comprehensive pharmacognostic evaluation, bioactive compound isolation, structural elucidation, and in silico analysis of Cissus quadrangularis L.

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Authors

KGKousik GhoshCentral Council for Research in Ayurvedic Science KGKarthick Muthaiah Palaniappan GopalCentral Council for Research in Ayurvedic Science LNLakshmanan NarayananCentral Council for Research in Ayurvedic Science

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Implication

In vitro and in silico analysis reveals high target binding affinities of beta-sitosterol isolated from Cissus quadrangularis, highlighting its potential for anti-inflammatory therapies.

Key Points

To evaluate the pharmacognostic profile of Cissus quadrangularis, isolate its primary bioactive constituents, and assess their therapeutic potential via computational modeling.
Standardized Cissus quadrangularis through macroscopic, microscopic, and phytochemical analyses following the Ayurvedic Pharmacopeia of India.
Isolated bioactive compounds from hexane extracts via column chromatography and identified them using FTIR, 1H NMR, 13C NMR, and mass spectrometry.
Conducted in silico molecular docking against hDHFR, eNOS, and TNF-α, followed by ADMET pharmacokinetic and drug-likeness evaluations.
Successfully isolated and structurally verified the phytosterol compound β-sitosterol from plant extracts.
Molecular docking demonstrated strong binding affinities for β-sitosterol against hDHFR (−10.95 kcal/mol), eNOS (−10.11 kcal/mol), and TNF-α (−7.64 kcal/mol).
In silico profiling confirmed favorable ADMET characteristics and promising drug-like properties.

Cite This Study

Ghosh et al. (2026) studied this question.

synapsesocial.com/papers/6a7e485b760ccf6bd0990e08 https://doi.org/10.1007/s44395-025-00035-z

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Implication

In vitro and in silico analysis reveals high target binding affinities of beta-sitosterol isolated from Cissus quadrangularis, highlighting its potential for anti-inflammatory therapies.

Comprehensive pharmacognostic evaluation, bioactive compound isolation, structural elucidation, and in silico analysis of Cissus quadrangularis L.

Discussion

Member takes

Implication

Key Points

Cite This Study

Comprehensive pharmacognostic evaluation, bioactive compound isolation, structural elucidation, and in silico analysis of Cissus quadrangularis L.

Discussion

Member takes

Implication

Key Points

Cite This Study

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