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This review examines the potential of biomaterial scaffolds in treating osteomyelitis through targeted antibacterial effects and bone regeneration.

Emerging trends of multifunctional biomaterial scaffolds for targeted antibacterial therapy and enhanced bone regeneration in osteomyelitis

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Randomized trial shows enhanced bone regeneration in osteomyelitis using multifunctional scaffolds, indicating a novel treatment approach.

This review examines the potential of biomaterial scaffolds in treating osteomyelitis through targeted antibacterial effects and bone regeneration.
Analysis of various biocompatible materials such as collagen, chitosan, and synthetic polymers like PLGA and PLA.
Review of novel antibiotic formulations for localized delivery and combination therapies with osteogenic agents.
Discussion of scaffold design optimization and stability improvements for clinical translation.
Biocompatible scaffolds effectively support bone repair while delivering antimicrobial agents to combat infections.
Combination therapies using scaffolds showed promise in overcoming biofilm resistance and enhancing tissue repair.
Scaffold designs significantly improved local antibiotic efficacy compared to standard systemic treatments.

Bhamare et al. (2026) studied this question.

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Randomized trial shows enhanced bone regeneration in osteomyelitis using multifunctional scaffolds, indicating a novel treatment approach.