Key result
Higher cerebral arterial stiffness, measured by carotid-cerebral pulse wave velocity, was positively associated with the degree of intracranial artery calcification in patients with acute ischemic stroke (OR 1.78 for highest vs lowest quartile).
Why the study?
This study aimed to determine the association of intracranial artery calcification with arterial stiffness using the newly defined carotid-cerebral pulse wave velocity in patients with acute stroke.
Is cerebral arterial stiffness (measured by ccPWV) associated with intracranial artery calcification in patients with acute ischemic stroke?
Cross-Sectional (n=146)
Yes
Is cerebral arterial stiffness (measured by ccPWV) associated with intracranial artery calcification in patients with acute ischemic stroke?
Odds Ratio: 1.78 (95% CI 1.28–2.5)
p-value: p=0.001
In patients with acute ischemic stroke, increased cerebral arterial stiffness (measured by carotid-cerebral pulse wave velocity) is independently associated with a higher degree of intracranial artery calcification.
IAC may mark cerebral stiffness in acute stroke; hypothesis-generating and leaves open any role in risk stratification.
Background and Purpose By measuring a newly defined parameter, the carotid-cerebral pulse wave velocity (ccPWV), this study aimed to determine the association of intracranial artery calcification (IAC) with arterial stiffness as reflected by the pulse wave velocity between the carotid and middle cerebral arteries using transcranial Doppler sonography in patients with acute stroke. MethodsWe recruited 146 patients with ischemic stroke from our stroke center.Computed tomography of the head was used to assess the presence and severity of IAC.Arterial stiffness was evaluated using ccPWV.Data are presented as quartiles of ccPWV.A multivariable logistic regression model was used to assess the independent relationship between ccPWV and IAC. ResultsThe IAC prevalence increased with the ccPWV quartile, being 54%, 76%, 83%, and 89% for quartiles 1, 2, 3, and 4, respectively (p<0.001) as did IAC scores, with median [interquartile range] values of 0 [0-2], 3 [2-4], 4 [2-5], and 5 [4-6], respectively (p<0.001).After additionally adjusting for age and hypertension, a significant correlation was only found between quartiles 3 and 4 of ccPWV and IAC scores.The odds ratio (95% confidence interval) for the IAC scores was 1.78 (1.28-2.50)(p=0.001) in quartile 4 of ccPWV and 1.45 (1.07-1.95)(p=0.015) in quartile 3 compared with quartile 1.Conclusions We found that in patients with acute ischemic stroke, ccPWV was positively related to the degree of IAC.Future longitudinal cohort studies may help to identify the potential role of IAC in the progression of cerebral arterial stiffness.
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Li et al. (2023) conducted a cross-sectional in Acute ischemic stroke (n=146). Carotid-cerebral pulse wave velocity (ccPWV) vs. Lowest quartile of ccPWV was evaluated on Intracranial artery calcification (IAC) score (OR 1.78, 95% CI 1.28-2.50, p=0.001). Higher cerebral arterial stiffness, measured by carotid-cerebral pulse wave velocity, was positively associated with the degree of intracranial artery calcification in patients with acute ischemic stroke (OR 1.78 for highest vs lowest quartile).
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