A New Model of Ventricular Plication: A Suturing Technique to Decrease Left Ventricular Dimensions, Improve Contractility, and Attenuate Ventricular Remodeling After Myocardial Infarction in the Rat Heart
Why the study?
Does ventricular plication by suturing improve left ventricular dimensions and contractility in a rat model of myocardial infarction?
Population
Rats with myocardial infarction induced by occluding the left coronary artery 4 weeks before enrollment (n=22)
Comparison
Ventricular plication using a pursestring suture… vs Pursestring suture placed within the border…
Design
Preclinical, Animals were randomized to a control or treatment group
Follow-up
6 to 7 weeks
Authors
Discussion
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Implication
Hypothesis-generating for post-MI plication in rodents; larger preclinical studies required before clinical translation.
Structured PICO
Does ventricular plication by suturing improve left ventricular dimensions and contractility in a rat model of myocardial infarction?
P
Population
Rats with myocardial infarction induced by occluding the left coronary artery 4 weeks before enrollment (n=22)
I
Intervention
Ventricular plication using a pursestring suture placed within the border zones of the infarcted area and tightened
C
Comparator
Pursestring suture placed within the border zones of the infarcted area but not tightened
O
Outcome
Left ventricular diameters (end-diastolic length, end-systolic length) and fractional shortening measured by echocardiography at 1 hour and 6 to 7 weeks after plicationsurrogate
Ventricular plication by suturing infarcted tissue acutely decreases left ventricular diameters and improves function, attenuating late ventricular remodeling in a rat model of myocardial infarction.
Cite This Study
Schwarz et al. (2000) studied this question.