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November 1, 1991CirculationOpen Access

Mechanism of ischemic mitral regurgitation. An experimental evaluation.

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Population

21 dogs divided into three groups for experimental evaluation of ischemic mitral regurgitation.

Comparison

Experimental induction of regional and global… vs Intact global LV function or intact papillary…

Design

Preclinical

Authors

SKSanjiv KaulCardiac ImagingWSWilliam D. SpotnitzDilon Technologies (United States)WGWilliam P. GlasheenVirginia Commonwealth University

Discussion

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Implication

Challenges papillary-centric model of ischemic MR; leaves open translation from canine data to clinical practice.

Structured PICO

P
Population
21 dogs divided into three groups (Group 1: n=8, Group 2: n=7, Group 3: n=6) for experimental evaluation of ischemic mitral regurgitation.
I
Intervention
Experimental induction of regional and global left ventricular (LV) dysfunction, or isolated papillary muscle dysfunction.
C
Comparator
Intact global LV function or intact papillary muscle function.
O
Outcome
Degree of mitral regurgitation assessed using contrast echocardiography.surrogate

Ischemic mitral regurgitation is driven by global left ventricular dysfunction leading to incomplete mitral leaflet closure, rather than isolated papillary muscle dysfunction.

Cite This Study

Kaul et al. (1991) studied this question.

synapsesocial.com/papers/6a2fa62a80b8ef8aeb5c6b28https://doi.org/10.1161/01.cir.84.5.2167

Topics

Mitral valve interventionEchocardiography
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