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March 1, 1981CirculationOpen Access

Incomplete mitral leaflet closure in patients with papillary muscle dysfunction.

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Why the study?

Is papillary muscle dysfunction associated with incomplete mitral leaflet closure and mitral regurgitation in patients with prior myocardial infarction?

Population

82 subjects: 22 patients with prior myocardial infarction and clinical evidence of papillary muscle…

Comparison

Echocardiographic examination vs Normal subjects and patients with prior…

Design

Cross-sectional

Authors

RGRobert W. GodleyLWL. Samüel WannERE W Rogers

Discussion

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Overview

Associates papillary muscle dyskinesis with post-MI mitral regurgitation; extends mechanistic insights but remains hypothesis-generating.

Structured PICO

Is papillary muscle dysfunction associated with incomplete mitral leaflet closure and mitral regurgitation in patients with prior myocardial infarction?

P
Population
82 subjects: 22 patients with prior myocardial infarction and clinical evidence of papillary muscle dysfunction, 40 patients with prior myocardial infarction and no clinical evidence of papillary muscle dysfunction, and 20 normal subjects.
I
Intervention
Echocardiographic examination
C
Comparator
Normal subjects and patients with prior myocardial infarction without clinical evidence of papillary muscle dysfunction
O
Outcome
Pattern of incomplete mitral leaflet closure and dyskinetic wall motionsurrogate

This study provides objective echocardiographic evidence that de novo mitral regurgitation in prior MI patients is caused by dyskinesis near the papillary muscles preventing normal leaflet closure.

Cite This Study

Godley et al. (1981) studied this question.

synapsesocial.com/papers/6a2fa62a80b8ef8aeb5c6b29https://doi.org/10.1161/01.cir.63.3.565
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