Key result
OxLDL stimulation induced rapid platelet-monocyte aggregate formation, facilitating monocyte extravasation and foam cell formation, which was significantly decreased by platelet depletion.
Population
In vitro cell models and in vivo mouse models (LDLR mice and wild-type mice)
Comparison
Oxidized low-density lipoprotein stimulation and… vs Resting platelets or non-depleted controls
Design
Preclinical
Authors
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Highlights platelet-monocyte role in atherogenesis; leaves open human translation and therapeutic targeting.
OxLDL-mediated platelet-monocyte interactions promote monocyte extravasation and foam cell formation, providing a novel mechanism for platelet involvement in atherosclerotic plaque development.
Badrnya et al. (2013) studied Atherosclerosis. Oxidized low-density lipoprotein (OxLDL) vs. Resting platelets / no OxLDL was evaluated on Platelet-monocyte aggregate formation, monocyte extravasation, and foam cell formation. OxLDL stimulation induced rapid platelet-monocyte aggregate formation, facilitating monocyte extravasation and foam cell formation, which was significantly decreased by platelet depletion.
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