Severe tricuspid regurgitation was an independent predictor of all-cause mortality (HR 2.93; 95% CI 1.57-5.49; p=0.001).
Cohort (n=1,650)
Moderate to severe tricuspid regurgitation, along with right ventricular dysfunction and elevated pulmonary pressures, are independent predictors of long-term mortality.
Hazard Ratio: 2.93 (95% CI 1.57–5.49)
p-value: p=0.001
OBJECTIVE: Functional tricuspid regurgitation (TR) is a frequent finding in echocardiography. Literature suggests significant TR is associated with poor prognosis. Still, data remain limited. This study aimed to evaluate long-term prognostic implications in patients with TR. METHODS: In this observational cohort study, data from 1650 consecutive patients were analysed. Primary endpoint was all-cause mortality. Mean follow-up time was 1090 days. TR grades at baseline and follow-up were compared. Survival analyses were performed to identify prognostic factors. RESULTS: At baseline, 14.1% patients showed no, 63.8% mild, 17.4% moderate and 4.7% severe TR. 359 patients (21.8%) died within the study period. TR at baseline was associated with excess mortality. Moderate and severe TR were of prognostic implication in all subgroups irrespective of systolic pulmonary artery pressure (sPAP) (</≥40 mm Hg) and left ventricular ejection fraction (LV-EF) (</≥50%). Survival was worst in patients with moderate and severe TR and concomitant elevated sPAP or reduced LV-EF at 1 and 3 years, respectively (p<0.001; p<0.001). In a multivariate model, including cardiac and non-cardiac risk factors, moderate and severe TR, sPAP and impaired right ventricular (RV) function were independent predictors for survival (HR 1.89, CI 1.07 to 3.36, p=0.029; HR 2.93, CI 1.57 to 5.49, p=0.001; HR 1.44, CI 1.25 to 1.65, p<0.001; HR 1.43, CI 1.14 to 1.79, p=0.002). Overall progression of TR on follow-up was 28.4%. Patients with TR progression showed significantly worse survival (HR 1.44, CI 1.11 to 1.81; p=0.006). CONCLUSION: While TR progressed over time, it was associated with impaired long-term survival. TR grade, RV dysfunction, sPAP and TR progression were independent predictors for survival.
Bannehr et al. (Mon,) conducted a cohort in Tricuspid regurgitation (n=1,650). Severe tricuspid regurgitation vs. No or mild tricuspid regurgitation was evaluated on All-cause mortality (HR 2.93, 95% CI 1.57 to 5.49, p=0.001). Severe tricuspid regurgitation was an independent predictor of all-cause mortality (HR 2.93; 95% CI 1.57-5.49; p=0.001).