Key result
Individuals with a coronary FAI-Score ≥90th percentile had a 3.5-fold (LAD), 5.5-fold (RCA), and 2-fold (LCX) higher adjusted risk of cardiac mortality compared to those below the 50th percentile.
Why the study?
Coronary computed tomography angiography-based fat attenuation index values require standardization for technical, anatomical, and biological factors before introduction for clinical risk stratification.
Does a higher FAI-Score on CCTA predict increased risk of cardiac mortality in patients undergoing clinically indicated CCTA?
Population
3912 individuals undergoing clinically indicated CCTA from the CRISP-CT study
Comparison
Higher vs lower FAI-Score percentiles across coronary arteries
Design
Multicenter observational cohort study
Follow-up
Median 5.6 years
Authors
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AI-powered FAI-Score on CCTA provides a standardized metric of coronary inflammation that strongly predicts cardiac mortality independent of traditional risk factors and existing atherosclerotic changes.
Cohort (n=3,912)
Yes
Does a higher FAI-Score on CCTA predict increased risk of cardiac mortality in patients undergoing clinically indicated CCTA?
Effect estimate: 3.5-fold (LAD), 5.5-fold (RCA), and 2-fold (LCX) higher risk
AI-powered FAI-Score on CCTA provides a standardized metric of coronary inflammation that strongly predicts cardiac mortality independent of traditional risk factors and existing atherosclerotic changes.
Oikonomou et al. (2021) conducted a cohort in Coronary inflammation (n=3,912). High FAI-Score (≥90th percentile) vs. FAI-Score <50th percentile was evaluated on Cardiac mortality (3.5-fold (LAD), 5.5-fold (RCA), and 2-fold (LCX) higher risk). Individuals with a coronary FAI-Score ≥90th percentile had a 3.5-fold (LAD), 5.5-fold (RCA), and 2-fold (LCX) higher adjusted risk of cardiac mortality compared to those below the 50th percentile.
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