Key result
Perivascular FAI predicts ~173% higher MACE risk but adds no incremental prognostic value over CACS.
Why the study?
It was unknown whether perivascular fat attenuation index adds prognostic value beyond that provided by SPECT-MPI and CCTA findings including coronary artery calcium scoring.
Does perivascular fat attenuation index (FAI) provide incremental prognostic value for MACE over SPECT-MPI and CACS in patients undergoing cardiac imaging?
Population
314 patients undergoing SPECT-MPI and CCTA at a single institution
Comparison
FAI prognostic value added to SPECT-MPI and CCTA findings including CACS
Design
Single-centre cohort study
Follow-up
Median of 2.7 years
Authors
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FAI should not yet refine MACE risk assessment beyond CACS; leaves open its incremental value in multimodality imaging.
Cohort (n=492)
No
Does perivascular fat attenuation index (FAI) provide incremental prognostic value for MACE over SPECT-MPI and CACS in patients undergoing cardiac imaging?
Hazard Ratio: 2.733 (95% CI 1.22–6.123)
p-value: p=0.015
Perivascular fat attenuation index (FAI) does not provide incremental prognostic value for major adverse cardiovascular events beyond standard multimodality imaging including coronary artery calcium scoring.
Bengs et al. (2020) conducted a cohort in Coronary artery disease (n=492). Perivascular fat attenuation index (FAI) vs. Low FAI (≤ -70.1 HU) was evaluated on Major adverse cardiovascular events (MACE) (HR 2.733, 95% CI 1.220-6.123, p=0.015). Perivascular fat attenuation index of the right coronary artery predicted MACE (HR 2.733) but did not provide incremental prognostic value after adding coronary artery calcium scoring (p=0.279).
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