Key result
This review highlights the multifactorial concept of arrhythmogenesis, where causal gene mutations are modified by factors like age, gender, sympathetic tone, and common genetic variations.
This review summarizes the current understanding of how common genetic variations in ion channel genes act as modifiers in the multifactorial development of cardiac arrhythmias.
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Supports consideration of modifiers in genetic arrhythmia risk; leaves open validation for clinical translation.
KAAB et al. (2005) conducted a review in Cardiac arrhythmias. Genetic variation in ion channel genes was evaluated. This review highlights the multifactorial concept of arrhythmogenesis, where causal gene mutations are modified by factors like age, gender, sympathetic tone, and common genetic variations.
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