Key result
Emergent aspiration thrombectomy successfully removes clot-in-transit and improves hemodynamics in a high-risk patient with PE.
Why the study?
Clot-in-transit carries high morbidity and mortality, particularly when coexisting with severe cardiomyopathy and left ventricular thrombus.
Case Report (n=1)
No
Percutaneous aspiration thrombectomy can be a feasible and effective minimally invasive option for selected high-risk patients presenting with clot-in-transit, acute pulmonary embolism, and severe biventricular dysfunction.
May support thrombectomy consideration in select high-risk acute HF with PE; leaves open need for prospective validation.
Clot-in-transit (CIT) is a life-threatening condition in which a venous thrombus is visualized within the right heart while migrating toward the pulmonary arteries. Its coexistence with severe cardiomyopathy and a left ventricular thrombus confers high morbidity and mortality. We report the case of a woman in her 40s with advanced heart failure with reduced ejection fraction (HFrEF), with a left ventricular ejection fraction (LVEF) of 10%-15%, who presented with acute pulmonary embolism (PE) , a large mobile thrombus traversing the tricuspid valve, and an apical left ventricular thrombus, complicated by cardiogenic shock. Given her hemodynamic instability and high surgical risk, she underwent emergent percutaneous aspiration thrombectomy using the FlowTriever device (Inari Medical, Inc., Irvine, CA), achieving successful clot removal and hemodynamic improvement. This case highlights the role of minimally invasive thrombectomy in selected high-risk patients.
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Eskandar et al. (2026) conducted a case report in Clot-in-transit, acute pulmonary embolism, and left ventricular thrombus in advanced heart failure (n=1). Percutaneous aspiration thrombectomy (FlowTriever) was evaluated on Clot removal and hemodynamic improvement. Emergent percutaneous aspiration thrombectomy achieved successful clot removal and hemodynamic improvement in a high-risk patient with clot-in-transit, pulmonary embolism, and severe heart failure.
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