Study on the mechanism of Wumei Pill （乌梅丸） in improving vascular endothelial function of obese mice

Q: What are the key findings of this study?

Wumei Pill improved vascular endothelial function in obese mice and reduced ox-LDL-induced injury by decreasing inflammation and oxidative stress (P<0.05).

Q: What is the clinical evidence from this study?

Population: Obesity-induced vascular endothelial dysfunction. Intervention: Wumei Pill (WMP) vs. Model group (saline) and ox-LDL group. Primary outcome: Body weight, blood lipids, MDA, catalase, inflammatory factors, and cell proliferation/apoptosis (p=<0.05).

Q: What question did this study set out to answer?

This study aims to explore the effects of Wumei Pill on vascular endothelial function and mechanisms of action against oxidized low-density lipoprotein-induced injury in obese mice.

Liang ZHAO; Xinna Huyan; Haodong ZHANG; Xiaocui WANG

doi:10.70976/j.1008-0805.szgygy-2026-1106

June 1, 2026Lishizhen medicine and materia medica research

Study on the mechanism of Wumei Pill （乌梅丸） in improving vascular endothelial function of obese mice

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Key result

Wumei Pill improves vascular endothelial function in obese mice by decreasing inflammation and oxidative stress.

P<0.05

Why the study?

To investigate the effect and mechanism of Wumei Pill on vascular endothelial function in obese mice and on ox-LDL-induced vascular endothelial injury.

Does Wumei Pill improve vascular endothelial function in obese mice and ox-LDL-induced endothelial cell injury?

Key Points

This study aims to explore the effects of Wumei Pill on vascular endothelial function and mechanisms of action against oxidized low-density lipoprotein-induced injury in obese mice.
High-fat diet induced obesity in mice, followed by randomization into multiple treatment groups including Wumei Pill and metformin.
Mice were treated over a 7-week intervention period, with assessments of body weight, serum lipid levels, and morphological changes.
In vitro analyses included cell proliferation, apoptosis, migration, and tube formation using HUVECs.
High-dose Wumei Pill group showed decreased body weight, lipid levels, and MDA levels (P<0.05), with increased catalase levels (P<0.01) and reduced inflammatory cytokines (P<0.001).
10% Wumei Pill group exhibited enhanced cell proliferation and migration (P<0.05) and reduced apoptosis (P<0.001) compared to ox-LDL treated cells.

Structured PICO

Does Wumei Pill improve vascular endothelial function in obese mice and ox-LDL-induced endothelial cell injury?

P

Population

High-fat diet-induced obese mice and ox-LDL-induced HUVECs treated with Wumei Pill to assess vascular endothelial function.

I

Intervention

Wumei Pill (WMP) at low, medium, and high doses via intragastric administration for 7 weeks (in vivo); 10% WMP (in vitro)

C

Comparator

Model group (saline), control group (saline), metformin group (in vivo); ox-LDL group (in vitro)

O

Outcome

Vascular endothelial function, aortic morphological changes, serum lipid levels, and inflammatory factors (in vivo); cell proliferation, apoptosis, tube formation, and migration (in vitro)surrogate

Main Result

p-value: p=<0.05

Wumei Pill improves vascular endothelial function in obese mice and protects against ox-LDL-induced endothelial injury by reducing inflammation and oxidative stress.

Implication

Hypothesis-generating in obese mice; should not yet change clinical practice or guide human trials.

Abstract

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Discussion

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Cite This Study

ZHAO et al. (2026) studied Obesity-induced vascular endothelial dysfunction. Wumei Pill (WMP) vs. Model group (saline) and ox-LDL group was evaluated on Body weight, blood lipids, MDA, catalase, inflammatory factors, and cell proliferation/apoptosis (p=<0.05). Wumei Pill improved vascular endothelial function in obese mice and reduced ox-LDL-induced injury by decreasing inflammation and oxidative stress (P<0.05).

synapsesocial.com/papers/6a31570faf7cf7f8256b3d3a https://doi.org/10.70976/j.1008-0805.szgygy-2026-1106

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Study on the mechanism of Wumei Pill （乌梅丸） in improving vascular endothelial function of obese mice

Key Points

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Study on the mechanism of Wumei Pill （乌梅丸） in improving vascular endothelial function of obese mice

Key Points

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

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