Key result
Higher urinary kynurenine-to-tryptophan ratio linked to ~43% greater major coronary event risk per SD in CAD.
Why the study?
Kynurenine synthesis from tryptophan may regulate vascular function in inflammatory conditions, but associations of urinary kynurenine to tryptophan ratio with cardiovascular events and mortality in suspected stable CAD required assessment.
Does the urine kynurenine to tryptophan ratio (KTR) predict cardiovascular events and mortality in patients with suspected stable CAD?
Population
3224 patients with suspected stable CAD undergoing elective coronary angiography
Comparison
Urinary kynurenine to tryptophan ratio levels
Design
Cohort study
Follow-up
Median 55 months
Authors
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Urine KTR may refine prognosis in suspected stable CAD; leaves open incremental value over standard risk models in prospective validation.
Cohort (n=3,224)
Does the urine kynurenine to tryptophan ratio (KTR) predict cardiovascular events and mortality in patients with suspected stable CAD?
Hazard Ratio: 1.43 (95% CI 1.29–1.59)
Elevated urinary kynurenine to tryptophan ratio (KTR) is a strong, independent predictor of major coronary events, myocardial infarction, and all-cause mortality in patients with suspected stable CAD.
Pedersen et al. (2013) conducted a cohort in suspected stable coronary artery disease (CAD) (n=3,224). Urinary kynurenine to tryptophan ratio (KTR) vs. Lower levels of urinary KTR was evaluated on Major coronary events (MCEs) (HR 1.43, 95% CI 1.29-1.59). Higher urinary kynurenine to tryptophan ratio was associated with an increased risk of major coronary events (HR 1.43; 95% CI 1.29-1.59) per standard deviation increment in patients with CAD.
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