Key result
Elevated plasma kynurenic acid (highest vs lowest quartile) was associated with an increased risk of acute myocardial infarction (HR 1.68; 95% CI 1.21-2.34) in patients with stable angina.
Why the study?
Do elevated plasma kynurenines predict an increased risk of acute myocardial infarction in patients with suspected stable angina pectoris?
Population
4122 patients with suspected stable angina pectoris who underwent elective coronary angiography, median age…
Comparison
Highest quartile of plasma kynurenines vs Lowest quartile of plasma kynurenines
Design
Cohort
Follow-up
median 56 months
Authors
Loading...
Kynurenine metabolites may aid AMI risk stratification in stable angina; leaves open incremental prognostic value and clinical adoption pending validation.
Cohort (n=4,122)
Do elevated plasma kynurenines predict an increased risk of acute myocardial infarction in patients with suspected stable angina pectoris?
Hazard Ratio: 1.68 (95% CI 1.21–2.34)
Elevated plasma kynurenines are associated with an increased risk of acute myocardial infarction in patients with stable angina, particularly those with pre-diabetes or diabetes.
Pedersen et al. (2014) conducted a cohort in Suspected stable angina pectoris (n=4,122). Elevated plasma kynurenines (highest quartile) vs. Lowest quartile of plasma kynurenines was evaluated on Acute myocardial infarction (HR 1.68, 95% CI 1.21-2.34). Elevated plasma kynurenic acid (highest vs lowest quartile) was associated with an increased risk of acute myocardial infarction (HR 1.68; 95% CI 1.21-2.34) in patients with stable angina.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: