Key result
Teichholz formula estimates LV mass with virtually no bias vs CMR, avoiding Devereux's ~22 g/m2 overestimation.
Why the study?
LV myocardial mass is important for evaluating cardiac remodeling and requires accurate assessment from linear 2D echocardiographic measurements compared to reference CMR.
Does the Teichholz formula improve the accuracy of echocardiographic left ventricular mass calculation compared to the Devereux formula across different geometric patterns?
Observational (n=1,502)
No
Does the Teichholz formula improve the accuracy of echocardiographic left ventricular mass calculation compared to the Devereux formula across different geometric patterns?
The Teichholz formula provides a more accurate estimation of left ventricular mass by echocardiography than the currently recommended Devereux formula, particularly in patients with altered left ventricular geometry.
Echocardiographers may favor Teichholz to limit LV mass overestimation; leaves open outcome validation in prospective HF cohorts.
Left ventricular (LV) myocardial mass is important in the evaluation of cardiac remodeling and requires accurate assessment when performed on linear measurements in two-dimensional echocardiography (Echo). We aimed to compare the accuracy of the Devereux formula (DEV) and the Teichholz formula (TEICH) in calculating LV myocardial mass in Echo using cardiac magnetic resonance (CMR) as the reference method. Based on preceding mathematical calculations, we identified primarily LV size rather than wall thickness as the main source of bias between DEV and TEICH in a retrospective derivation cohort (n = 1276). Although LV mass from DEV and TEICH were correlated with CMR, TEICH did not show a proportional bias as did DEV (− 2 g/m 2 vs. + 22 g/m 2 ). This could be validated in an independent prospective cohort (n = 226) with symptomatic non-ischemic heart failure. DEV systematically overestimated LV mass in all tiers of LV remodeling as compared to TEICH. In conclusion, the TEICH method accounts for the changes in LV geometry with increasing LV mass and thus better reflects the different pattern of LV remodeling than the DEV method. This has important clinical implications, as TEICH may be more appropriate for use in clinical practice, rather than DEV, currently recommended.
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Sveric et al. (2023) conducted an observational in Cardiac remodeling and heart failure (n=1,502). Teichholz formula (TEICH) vs. Devereux formula (DEV) was evaluated on Measurement bias of left ventricular mass compared to cardiac magnetic resonance imaging. The Teichholz formula for calculating left ventricular mass showed virtually no proportional bias compared to cardiac magnetic resonance imaging (-2 g/m2), whereas the currently recommended Devereux formula systematically overestimated mass (+22 g/m2).
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