Key result
Cardiomyocyte-specific ERβ overexpression improved survival 2 weeks after myocardial infarction compared to wild-type in both female (100% vs 76%) and male (83% vs 58%) mice.
Why the study?
Does cardiomyocyte-specific oestrogen receptor β overexpression improve survival and cardiac function after myocardial infarction in mice?
Population
Female and male mice subjected to chronic anterior coronary artery ligation or sham surgery
Comparison
Cardiomyocyte-specific oestrogen receptor β… vs Wild-type (WT) littermates
Design
Preclinical
Follow-up
2 weeks
Authors
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Suggests ERβ as a potential post-MI target; leaves open human translation.
Does cardiomyocyte-specific oestrogen receptor β overexpression improve survival and cardiac function after myocardial infarction in mice?
Cardiomyocyte-specific ERβ overexpression improves survival, reduces maladaptive remodeling, and preserves cardiac function after myocardial infarction in both male and female mice.
Schuster et al. (2015) studied Myocardial infarction. Cardiomyocyte-specific ERβ overexpression vs. Wild-type (WT) littermates was evaluated on Survival at 2 weeks after MI. Cardiomyocyte-specific ERβ overexpression improved survival 2 weeks after myocardial infarction compared to wild-type in both female (100% vs 76%) and male (83% vs 58%) mice.
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