Why the study?
Does 17beta-estradiol prevent left ventricular hypertrophy in ovariectomized female mice undergoing transverse aortic constriction?
Population
Ovariectomized female wild-type, ERalpha-deficient, and ERbeta-deficient mice undergoing transverse aortic…
Comparison
17beta-estradiol administered subcutaneously… vs Placebo administered subcutaneously using 60-day…
Design
Preclinical
Authors
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Suggests ERβ mediates estradiol's protection against pressure-overload hypertrophy in mice; leaves open translation to human LVH prevention.
Does 17beta-estradiol prevent left ventricular hypertrophy in ovariectomized female mice undergoing transverse aortic constriction?
17beta-estradiol protects against pressure overload-induced left ventricular hypertrophy specifically through estrogen receptor beta-mediated mechanisms in a murine model.
Babiker et al. (2006) studied this question.
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