Why the study?
Does 17beta-estradiol inhibit angiotensin II-induced cardiac hypertrophy in female mice?
Does 17beta-estradiol inhibit angiotensin II-induced cardiac hypertrophy in female mice?
17beta-estradiol inhibits angiotensin II-induced cardiac hypertrophy and fibrosis in female mice primarily through the estrogen receptor-beta isoform and subsequent inhibition of calcineurin activity.
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Animal findings implicate ERβ in E2-mediated hypertrophy reversal; human trials needed before clinical consideration.
Pedram et al. (2008) studied this question.
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