Key result
17beta-estradiol treatment reduced cardiac hypertrophy by 31% and 26% compared with placebo at 4 and 8 weeks after transverse aortic constriction in ovariectomized mice.
Why the study?
Does 17beta-estradiol reduce cardiac hypertrophy in ovariectomized mice subjected to pressure overload?
Population
Ovariectomized mice undergoing transverse aortic constriction (TAC) or sham operation
Comparison
17beta-estradiol (E2) vs Placebo
Design
Preclinical
Follow-up
8 weeks
Authors
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May support preclinical exploration of estrogen in hypertrophy; leaves open human translation.
Does 17beta-estradiol reduce cardiac hypertrophy in ovariectomized mice subjected to pressure overload?
17beta-estradiol attenuates the hypertrophic response to pressure overload in ovariectomized mice, suggesting a direct cardioprotective mechanism for estrogen.
Eickels et al. (2001) studied Pressure-overload hypertrophy. 17beta-estradiol (E2) vs. Placebo was evaluated on Cardiac hypertrophy. 17beta-estradiol treatment reduced cardiac hypertrophy by 31% and 26% compared with placebo at 4 and 8 weeks after transverse aortic constriction in ovariectomized mice.
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