January 1, 2012International Heart JournalOpen Access

Activation of Peripheral Blood CD3+ T-lymphocytes in Patients With Atrial Fibrillation

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Why the study?

Are peripheral blood CD3+ T-lymphocytes activated in patients with atrial fibrillation, and do their activation markers change following electrical cardioversion?

Population

157 subjects, comprising 50 patients with paroxysmal atrial fibrillation and 56 patients with persistent AF…

Comparison

Measurement of CD69 and HLA-DR expression on… vs Healthy volunteers with no history of…

Design

Cohort

Follow-up

3 months

Authors

LLLi LiuShihezi University JLJun LeeUlsan College GFGuoqiang FuShanghai University of Traditional Chinese Medicine

Discussion

Member takes

Implication

CD69/HLA-DR elevation associates with AF and post-cardioversion recurrence; hypothesis-generating for T-cell activation's role but should not yet change practice.

Structured PICO

Are peripheral blood CD3+ T-lymphocytes activated in patients with atrial fibrillation, and do their activation markers change following electrical cardioversion?

Population

157 subjects, comprising 50 patients with paroxysmal atrial fibrillation (AF) and 56 patients with persistent AF who underwent successful electrical cardioversion, plus 51 healthy controls. Mean age ~64-67 years, 61-64% male, based in China. Key exclusions: infectious diseases, immunological diseases, anti-inflammatory or immunosuppression treatment, recent trauma/surgery, coronary heart disease, myocardiopathy, rheumatic heart disease, valvular heart disease, heart failure, chronic lung diseases, hepatic and renal diseases, and cancer.

Intervention

Measurement of CD69 and HLA-DR expression on peripheral blood CD3+ T-lymphocytes before and 3 months after electrical cardioversion.

Comparator

Healthy volunteers with no history of arrhythmias (for baseline comparison) and patients with AF recurrence versus those maintaining sinus rhythm (for 3-month follow-up comparison).

Outcome

Percentage of CD69 and human leukocyte antigen DR (HLA-DR) positive peripheral blood CD3+ T-lymphocytes measured by flow cytometric analysis.surrogate

Peripheral blood CD3+ T-lymphocyte activation markers CD69 and HLA-DR are elevated in patients with atrial fibrillation and decrease upon successful maintenance of sinus rhythm, suggesting a role for systemic inflammation in AF.

Limitations

Results cannot be taken as evidence that supports roles for CD69 and HLA-DR in the pathogenesis of AF; they only indicate possible association.
How CD69 and HLA-DR contribute to the pathogenesis of AF and the exact details of the underlying mechanism need to be further investigated.
Did not study the influence of other immune activation-associated molecules (CD25, CD71, CD122) and co-stimulatory molecules (CD28, CTLA-4, CD80, CD86) during the progression of AF.

Cite This Study

Liu et al. (2012) studied this question.

synapsesocial.com/papers/6a321dc7aaf0ec54eae45e01 https://doi.org/10.1536/ihj.53.221

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF AF ablation outcomes

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Implication

CD69/HLA-DR elevation associates with AF and post-cardioversion recurrence; hypothesis-generating for T-cell activation's role but should not yet change practice.

Activation of Peripheral Blood CD3+ T-lymphocytes in Patients With Atrial Fibrillation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Activation of Peripheral Blood CD3+ T-lymphocytes in Patients With Atrial Fibrillation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider