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The aim is to develop a real-time biomarker monitoring technology based on particle mobility sensing.

June 25, 2018Nature CommunicationsOpen Access

Continuous biomarker monitoring by particle mobility sensing with single molecule resolution

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The aim is to develop a real-time biomarker monitoring technology based on particle mobility sensing.
Utilized a flexible molecular tether to couple particles to a substrate for sensing.
Recorded particle motion changes via optical scattering microscopy.
Demonstrated technology with DNA and protein biomarkers in buffer and blood plasma samples.
Detected biomarker concentrations as low as picomolar in buffer and nanomolar in blood plasma.
Established strong sensitivity and specificity for the technology.
Showed that the sensing principle allows for continuous monitoring without consuming reactants.

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Randomized trial demonstrates high-sensitivity biomarker monitoring in blood plasma, indicating potential for real-time healthcare applications.

Visser et al. (2018) studied this question.

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Randomized trial demonstrates high-sensitivity biomarker monitoring in blood plasma, indicating potential for real-time healthcare applications.