Why the study?
Does chronic caffeine treatment alter cardiac adenosine receptor function, heart rate, and blood pressure in rats?
Population
Anaesthetized rats
Comparison
Caffeine (0.2%) in drinking water for 2 weeks vs Tap water alone for 2 weeks
Design
Preclinical
Follow-up
2 weeks
Authors
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Hypothesis-generating for A1 sensitization in rats; does not support changes in human caffeine recommendations.
Does chronic caffeine treatment alter cardiac adenosine receptor function, heart rate, and blood pressure in rats?
Chronic caffeine intake in rats increases resting heart rate and blood pressure, concurrent with sensitization of A1 adenosine receptor-mediated bradycardic responses.
White et al. (2002) studied this question.
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