Why the study?
Does caffeine antagonize the cardiovascular effects of adenosine in normotensive male subjects?
Population
10 normotensive male subjects
Comparison
Caffeine 250 mg intravenously prior to adenosine… vs Placebo
Design
RCT, randomized, double-blind
Authors
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Caffeine may blunt adenosine responses in testing or therapy; confirms in vivo antagonism of hemodynamic and neurohormonal effects.
Does caffeine antagonize the cardiovascular effects of adenosine in normotensive male subjects?
Caffeine significantly attenuates the hemodynamic and neurohormonal effects of adenosine in humans, demonstrating in vivo antagonism.
Smits et al. (1987) studied this question.
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