Key result
Intracerebroventricular caffeine enhances hydralazine-induced renal renin secretion and norepinephrine spillover in rats.
Why the study?
Does intracerebroventricular caffeine enhance hydralazine-induced renal renin secretion and norepinephrine spillover in anesthetized rats?
Population
Anesthetized rats
Comparison
Intracerebroventricular infusions of caffeine vs Control animals
Design
Preclinical
Authors
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Central caffeine augments reflex renin release in rats; hypothesis-generating for CNS adenosine modulation of sympathetic-renin axis in humans.
Does intracerebroventricular caffeine enhance hydralazine-induced renal renin secretion and norepinephrine spillover in anesthetized rats?
p-value: p=0.03
Central administration of caffeine in rats enhances hydralazine-induced renal renin secretion and norepinephrine spillover, supporting a central nervous system adenosine brake on renin release.
Tofovic et al. (1996) studied this question. Intracerebroventricular (i.c.v.) caffeine vs. Control was evaluated on Hydralazine-induced changes in renal secretion of renin (p=0.03). Intracerebroventricular caffeine significantly enhanced hydralazine-induced increases in renal renin secretion (p=0.03) and renal norepinephrine spillover (p=0.035) in anesthetized rats.
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