July 1, 1987Journal of Clinical InvestigationOpen Access

Caffeine enhances the slow-pressor response to angiotensin II in rats. Evidence for a caffeine-angiotensin II interaction with the sympathetic nervous system.

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Why the study?

Does caffeine enhance the pressor response to angiotensin II in rats?

Population

Male Sprague Dawley rats. Chronic infusion study: intact rats and sympathectomized rats pretreated with…

Comparison

Caffeine combined with chronic low-dose… vs Angiotensin II infusion alone in intact or…

Design

Preclinical, Rats were selected at random for in situ perfusion; overall group…

Follow-up

12 days

Authors

AOAkihiro OhnishiTokyo University of Agriculture PLP LiWake Forest University RBRobert A. BranchUniversity of Southern California

Discussion

Member takes

Implication

Cautions against clinical extrapolation from rats; leaves open sympathetic mechanisms in angiotensin II hypertension models.

Structured PICO

Does caffeine enhance the pressor response to angiotensin II in rats?

Population

Male Sprague Dawley rats (n=65 total). Chronic infusion study: intact rats (n=18) and sympathectomized rats pretreated with 6-hydroxydopamine (n=20). Acute infusion study: n=27 rats.

Intervention

Caffeine (0.1% in drinking water) combined with chronic low-dose angiotensin II (125 ng/min i.p. for 12 days) or acute intravenous angiotensin II.

Comparator

Angiotensin II infusion alone (without caffeine) in intact or sympathectomized rats.

Outcome

Systolic blood pressure (SBP) over 12 days for chronic infusion; mean arterial blood pressure for acute infusion.surrogate

Caffeine augments the slow-pressor effect of chronic low-dose angiotensin II via a mechanism involving the sympathetic nervous system in rats.

Cite This Study

Ohnishi et al. (1987) studied this question.

synapsesocial.com/papers/6a84881adc9bcdcbf8c6ca4f https://doi.org/10.1172/jci113038

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Caffeine enhances the slow-pressor response to angiotensin II in rats. Evidence for a caffeine-angiotensin II interaction with the sympathetic nervous system.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Caffeine enhances the slow-pressor response to angiotensin II in rats. Evidence for a caffeine-angiotensin II interaction with the sympathetic nervous system.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider