July 22, 2003HypertensionOpen Access

Low-Dose Angiotensin II Enhances Pressor Responses Without Causing Sustained Hypertension

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Population

Sprague-Dawley rats with implanted telemetry

Comparison

Subpressor doses of Angiotensin II via osmotic… vs Vehicle via osmotic minipumps

Design

Preclinical

Follow-up

13 days

Authors

LPLaura I. PelaezMayo Clinic MMMelissa C. ManriquezMayo Clinic KNKarl A. NathUniversity of Bergamo

Discussion

Member takes

Implication

Subpressor Ang II may magnify BP reactivity to minor stressors in rats; leaves open mechanistic relevance to human hypertension.

Structured PICO

Population

Sprague-Dawley rats with implanted telemetry

Intervention

Subpressor doses of Angiotensin II (50 ng/kg per minute) via osmotic minipumps for 13 days

Comparator

Vehicle via osmotic minipumps

Outcome

Systolic blood pressure measured continuously by telemetry in unrestrained state and during tail cuff plethysmography (TCP)surrogate

Subpressor doses of Angiotensin II magnify the pressor response to trivial stimuli without causing sustained hypertension in unrestrained rats.

Cite This Study

Pelaez et al. (2003) studied this question.

synapsesocial.com/papers/6a885ac4af2c2bd0114dee64 https://doi.org/10.1161/01.hyp.0000085782.99773.b6

Topics

Hypertension management

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Low-Dose Angiotensin II Enhances Pressor Responses Without Causing Sustained Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Low-Dose Angiotensin II Enhances Pressor Responses Without Causing Sustained Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider