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June 17, 2026Brain Research BulletinOpen Access

Assessing the effect of long-term high altitude exposure on human brain function: A resting-state functional magnetic resonance imaging study

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Authors

ZWZhidong WangJCJiajie ChenXDXiaofeng Dai

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Overview

Randomized trial assesses brain function in high-altitude conditions, suggesting hypoxia impacts neuronal activity.

Key Points

  • This research aims to evaluate how long-term exposure to high altitude affects human brain function using fMRI.
  • Utilized resting-state functional magnetic resonance imaging (fMRI) to measure brain activity.
  • Compared 47 low-altitude, 39 high-altitude, and 34 ultra-high-altitude individuals regarding ReHo and DC values.
  • Analyzed correlations with heart rate and blood oxygen saturation (SpO₂).
  • UHA/HA participants exhibited significantly lower ReHo values in various brain regions compared to the LA group, correlated with SpO₂.
  • Increased ReHo was found in the occipital and superior parietal lobes, negatively correlated with SpO₂.
  • DC values were significantly lower in key areas, also positively correlated with SpO₂.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a3239c2d50b63ecad205191https://doi.org/10.1016/j.brainresbull.2026.112008
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