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This study analyzes the relationship between serum creatine kinase levels, acute kidney injury, and renal outcomes in adults with rhabdomyolysis.

Acute kidney injury in rhabdomyolysis defined by serum creatine kinase ≥1000 IU/L: association with creatine kinase levels

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Cohort study analyzes acute kidney injury outcomes related to creatine kinase levels in adults, suggesting the need for preventive measures.

This study analyzes the relationship between serum creatine kinase levels, acute kidney injury, and renal outcomes in adults with rhabdomyolysis.
Single-centre cohort study involving 855 patients with serum CK over 1000 IU/L.
Performed univariate and multivariate analyses using logistic regression and cox proportional hazards models.
Followed patients for renal function recovery and mortality outcomes.
AKI developed in 368 out of 855 patients (43%), with higher CK levels correlating with more severe AKI stages.
Of patients with AKI who survived beyond 3 years, 87.4% achieved complete renal recovery.
Serum CK levels over 5000 IU/L predicted severe AKI and the need for renal replacement therapy but did not affect long-term mortality.

Khor et al. (2026) studied this question.

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Cohort study analyzes acute kidney injury outcomes related to creatine kinase levels in adults, suggesting the need for preventive measures.