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June 17, 2026Particle and Fibre ToxicologyOpen Access

Degradation reshapes the toxic identity of polylactic acid microplastics through MSR1-dependent immune decoding in mouse kidney

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Authors

XCXiaoqing ChenYDYanhong DengXHXiyun Huang

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Overview

Randomized trial investigates inflammatory damage from polylactic acid microplastics in mice, suggesting an urgent reevaluation of their safety.

Key Points

  • This research aims to understand how the degradation of polylactic acid microplastics alters their toxicity profile, particularly in kidney tissues.
  • Mice were exposed to polymeric and oligomeric polylactic acid microplastics over 28 days.
  • In vitro transcriptomic analyses were conducted to explore nephrotoxicity mechanisms.
  • Effects of inhibiting MSR1 and PI3K/AKT on cytokine production and kidney injury were evaluated.
  • PLA oligomer microplastics accumulated significantly more in kidneys compared to polymer microplastics.
  • Oligomer exposure triggered severe inflammatory damage linked to MSR1-mediated mechanisms.
  • Inhibition of MSR1 or PI3K/AKT substantially reduced macrophage infiltration and renal injury.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a323a2ad50b63ecad20560fhttps://doi.org/10.1186/s12989-026-00690-9
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