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September 10, 2025Journal of Advanced Research0 citationsOpen Access

Hepatotoxicity from Polylactic Acid Microplastics Mediated by Gut Microbiota and Uric Acid

Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism

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Authors

YDYanhong DengZLZhiming LiYHYuji Huang

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Overview

This research investigates hepatotoxicity driven by microplastics in mice, suggesting gut microbiota and uric acid play key roles.

Key Points

  • Exposure to polylactic acid microplastics disrupted gut microbiota and increased uric acid levels, causing liver inflammation.
  • The study showed that elevated uric acid led to upregulation of Hsd17b13 mRNA and accumulation of triglycerides in the liver.
  • In vivo multi-omics analyses were used to uncover mechanisms of hepatotoxicity linked to gut microbiota alterations in mice.
  • Findings indicate that clearing intestinal microbiota can reduce PLA microplastic-induced liver injury, emphasizing systemic factors.
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Cite This Study

Deng et al. (2025) studied this question.

synapsesocial.com/papers/68c189d99b7b07f3a061368dhttps://doi.org/10.1016/j.jare.2025.08.055
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Degradation reshapes the toxic identity of polylactic acid microplastics through MSR1-dependent immune decoding in mouse kidney2026
  2. 2Gastrointestinal Incomplete Degradation Exacerbates Neurotoxic Effects of PLA Microplastics via Oligomer Nanoplastics Formation2024 · 46 citations
  3. 3Uncovering the Hidden Risks: How PLA and PLGA Microplastics Disrupt Gut Microbiota and Metabolic Health2026
  4. 4Polylactic acid micro/nanoplastic-induced hepatotoxicity: Investigating food and air sources via multi-omics2024 · 32 citations
  5. 5Exposure to polylactic acid microplastics during puberty increases the risk of skeletal dysplasia by disrupting arachidonic acid metabolism in osteoblasts2026