Homogalacturonan-rich pectin polysaccharides from Pyracantha fortuneana ameliorate dextran sulfate sodium–induced colitis via mucosal barrier and gut microbiota

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Key Points

The study aims to explore the effects of a novel pectin polysaccharide from Pyracantha fortuneana on colitis and gut microbiota.
Isolation of pectin polysaccharide (PFP) from Pyracantha fortuneana using acid extraction and ultrafiltration.
In vivo evaluation of PFP's effects on DSS-induced colitis in mice.
Assessment of intestinal barrier function, weight loss, disease activity index, and gut microbiota composition.
PFP significantly improved intestinal barrier function and reduced weight loss (percentage change not specified).
Colitis symptoms were alleviated with a notable decrease in disease activity index (exact data not specified).
PFP increased Bacteroidetes and Bacteroides while decreasing Proteobacteria, indicating beneficial microbiota modulation.

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Examines the effect of pectin polysaccharides on gut health in colitis, indicating potential therapeutic benefits.

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Lv et al. (2026) studied this question.

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