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June 17, 2026MaterialsOpen Access

Sintering Method-Dependent Hydroxyapatite Coatings Drive Enhanced Gingival Fibroblast Behavior on Titanium Implant Surfaces

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Authors

AVAndreia Luís VieiraNSN. SahooBFBeatriz Ferreira Fernandes

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Overview

Randomized trial reports enhanced fibroblast behavior on titanium implants with optimized hydroxyapatite sintering, indicating improved biocompatibility.

Key Points

  • This study aims to evaluate how different sintering methods for hydroxyapatite coatings affect the behavior of gingival fibroblasts on titanium implants.
  • Titanium discs were prepared using Nd:YVO4 laser texturing and coated with hydroxyapatite through conventional or laser sintering.
  • Human gingival fibroblasts were cultured on the discs to assess adhesion, morphology, viability, and cytokine secretion.
  • The study included seven groups based on titanium surface patterns and coating methods.
  • Hydroxyapatite coatings significantly reduced fibroblast viability for conventional sintering (p < 0.05), but not for laser sintering (p > 0.05).
  • Cytokine secretion showed a favorable profile in the 0.25 mm pattern compared to the 0.8 mm pattern; specifically, IL-1β levels decreased while IL-10 levels increased by day 3 with the optimized coatings.
  • The IL-1β/viability ratio was significantly lower for TiT08 compared to TiT08CS (p < 0.05).

Cite This Study

Vieira et al. (2026) studied this question.

synapsesocial.com/papers/6a323b4cd50b63ecad205e89https://doi.org/10.3390/ma19122573
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biocompatibility of dental implants coated with hydroxyapatite using pulsed Er:YAG laser deposition2024 · 5 citations
  2. 2Enhancement of Antibacterial and Cytocompatibility Characteristics of Hydrophobic and Hydrophilic Titanium Surfaces Fabricated by Femtosecond Laser Processing2026
  3. 3Investigate The Applicability of Coating Titanium Substrate by Hydroxyapatite for Surgical Implants2024 · 4 citations
  4. 4Laser surface texturing of Ti-cp and Ti6Al4V alloy for the improvement of fibroblast adhesion and alignment and the reduction of bacterial adhesion2024 · 38 citations
  5. 5TiN-coated abutment microtopographies promote gingival fibroblast-mediated soft-tissue sealing and reduce biofilm formation in vitro2026