Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 19, 2026BMC Oral HealthOpen Access

TiN-coated abutment microtopographies promote gingival fibroblast-mediated soft-tissue sealing and reduce biofilm formation in vitro

View Full Paper
Ask AI
Bookmark
Share

Authors

TRTea RomascoSPSanja PetrovićTTTamara Vlajić Tovilović

Discussion

Loading...

Member takes

Overview

In vitro study demonstrates enhanced fibroblast adhesion and reduced biofilm formation on TiN-coated microtopographies, indicating improved soft-tissue integration for dental abutments.

Key Points

  • To evaluate the combined effects of micro-topographical design and titanium nitride (TiN) coating on human gingival fibroblast behavior and bacterial biofilm formation.
  • Characterized surface topography, wettability, and biocompatibility across six TiN-coated surfaces with machined (M, M1, M2) or double-acid-etched (T, T1, T2) micro-thread geometries.
  • Assessed human gingival fibroblast (HGF) viability, attachment, and mechanotransduction markers (FAK, YAP, and TAZ) using MTT, SEM, and immunofluorescence analyses.
  • Measured bacterial adhesion and biofilm reduction across multiple bacterial species compared with uncoated and alternative micro-thread surfaces.
  • All TiN-coated surfaces were biocompatible and moderately hydrophilic, with the acid-etched T1 surface (50 × 5 μm thread geometry) yielding superior HGF viability and adhesion.
  • The T1 surface promoted mechanotransduction via increased activation of FAK, YAP, and TAZ along with reduced levels of their phosphorylated forms.
  • TiN coating significantly reduced biofilm formation across tested bacterial species relative to uncoated surfaces, with T1 achieving marked biofilm reduction compared to M1.

Cite This Study

Romasco et al. (2026) studied this question.

synapsesocial.com/papers/6a8563fe03308d306e2d7870https://doi.org/10.1186/s12903-026-09607-6
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthesis of titanium nitride-coated titanium dioxide nanotubes and an investigation into their compatibility with human gingival fibroblasts2025
  2. 2Nanostructured Implant–Tissue Interface Assessment Using a Three-Dimensional Gingival Tissue Equivalent2024 · 7 citations
  3. 3Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an <i>in vitro</i> and <i>in vivo</i> study2015 · 44 citations
  4. 4Balancing Osseointegration and Infection Control: The Role of Titanium Surface Topography in Peri-Implant Biology2026
  5. 5Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant2024 · 3 citations